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Article

Receptor inhibition of pheromone signaling is mediated by the Ste4p Gbeta subunit.

Molecular and cellular biology - 1 Jan 1999

Kim J, Couve A, Hirsch J P

Abstract excerpt

The pheromone response pathway of the yeast Saccharomyces cerevisiae is initiated in MATa cells by binding of alpha-factor to the alpha-factor receptor. MATa cells in which the a-factor receptor is inappropriately expressed exhibit reduced pheromone signaling, a phenomenon termed receptor inhibition. In cells undergoing receptor inhibition, activation of the signaling pathway occurs normally at early time points...

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Identifiers

PMID: 9858568
DOI: 10.1128/MCB.19.1.441
PMCID: PMC83902

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Receptor inhibition of pheromone signaling is mediated by the Ste4p Gbeta subunit.PMID 9858568Read ↗

The Leu-132 of the Ste4(Gbeta) subunit is essential for proper coupling of the G protein with the Ste2 alpha factor receptor during the mating pheromone response in yeast.Semantic proximity Read ↗

The C terminus of the Saccharomyces cerevisiae alpha-factor receptor contributes to the formation of preactivation complexes with its cognate G protein.Semantic proximity Read ↗

Feedback phosphorylation of the yeast a-factor receptor requires activation of the downstream signaling pathway from G protein through mitogen-activated protein kinase.Semantic proximity Read ↗

Constitutive mutants of the protein kinase STE11 activate the yeast pheromone response pathway in the absence of the G protein.Semantic proximity Read ↗

Biochemical analysis of yeast G(alpha) mutants that enhance adaptation to pheromone.Semantic proximity Read ↗

Regulation of the yeast pheromone response pathway by G protein subunits.Semantic proximity Read ↗

Switch-domain mutations in the Saccharomyces cerevisiae G protein alpha-subunit Gpa1p identify a receptor subtype-biased mating defect.Semantic proximity Read ↗

Genetic relationships between the G protein beta gamma complex, Ste5p, Ste20p and Cdc42p: investigation of effector roles in the yeast pheromone response pathway.Semantic proximity Read ↗

STE2/SCG1-dependent inhibition of STE4-induced growth arrest by mutant STE4 delta C6 in the yeast pheromone response pathway.Semantic proximity Read ↗

Analysis of the receptor binding domain of Gpa1p, the G(alpha) subunit involved in the yeast pheromone response pathway.Semantic proximity Read ↗

Genetic fine-structural analysis of the Saccharomyces cerevisiae alpha-pheromone receptor.Semantic proximity Read ↗

Disruption of receptor-G protein coupling in yeast promotes the function of an SST2-dependent adaptation pathway.Semantic proximity Read ↗

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