Article
Constitutive mutants of the protein kinase STE11 activate the yeast pheromone response pathway in the absence of the G protein.
Genes & development - 1 Jul 1992
Stevenson B J, Rhodes N, Errede B, Sprague G F
Abstract excerpt
STE4 encodes the beta-subunit of a heterotrimeric guanine nucleotide-binding protein (G protein) that is an early and essential component of the pheromone signal transduction pathway. From a ste4 deletion strain we have isolated both dominant and recessive suppressors that show increased transcri...
Topics
- Alleles
- Cloning, Molecular
- Fungal Proteins
- GTP-Binding Proteins
- Genes, Fungal
- MAP Kinase Kinase Kinases
- Mating Factor
- Peptides
- Phenotype
- Pheromones
- Phosphorylation
- Protein Processing, Post-Translational
- Protein-Tyrosine Kinases
- Saccharomyces cerevisiae Proteins
- Signal Transduction
- Suppression, Genetic
- Transcription, Genetic
- Yeasts