Article
Retinal degeneration but not obesity is observed in null mutants of the tubby-like protein 1 gene.
Human molecular genetics - 22 Jan 2000
Ikeda S, Shiva N, Ikeda A, Smith R S, Nusinowitz S, Yan G, Lin T R, Chu S, Heckenlively J R, North M A, Naggert J K, Nishina P M, Duyao M P
Abstract excerpt
The tub gene is a member of a small, well conserved neuronal gene family of unknown function. Mutations within this gene lead to early-onset blindness and deafness, as well as late-onset obesity and insulin resistance. To test the hypothesis that mutations within other members of this gene family would lead to similar phenotypes as observed in tubby mice, and hence have similar functional properties, we have...
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