Article
Targeted deletion of the tub mouse obesity gene reveals that tubby is a loss-of-function mutation.
Molecular and cellular biology - 1 Feb 2000
Stubdal H, Lynch C A, Moriarty A, Fang Q, Chickering T, Deeds J D, Fairchild-Huntress V, Charlat O, Dunmore J H, Kleyn P, Huszar D, Kapeller R
Abstract excerpt
The mouse tubby phenotype is characterized by maturity-onset obesity accompanied by retinal and cochlear degeneration. A positional cloning effort to find the gene responsible for this phenotype led to the identification of tub, a member of a novel gene family of unknown function. A splice defect mutation in the 3' end of the tub gene, predicted to disrupt the C terminus of the Tub protein, has been implicated in...
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