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Article

Drosophila king tubby (ktub) mediates light-induced rhodopsin endocytosis and retinal degeneration.

Journal of biomedical science - 10 Dec 2012

Chen Shu-Fen, Tsai Yu-Chen, Fan Seng-Sheen

Abstract excerpt

BACKGROUND: The tubby (tub) and tubby-like protein (tulp) genes encode a small family of proteins found in many organisms. Previous studies have shown that TUB and TULP genes in mammalian involve in obesity, neural development, and retinal degeneration. The purpose of this study was to investigate the role of Drosophila king tubby (ktub) in rhodopsin 1 (Rh1) endocytosis and retinal degeneration upon light...

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Source

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Identifiers

PMID: 23228091
DOI: 10.1186/1423-0127-19-101
PMCID: PMC3541268

Genes

TUB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Drosophila king tubby (ktub) mediates light-induced rhodopsin endocytosis and retinal degeneration.PMID 23228091Read ↗

A role for the Tubby-like protein 1 in rhodopsin transport.Semantic proximity Read ↗

Retinal degeneration but not obesity is observed in null mutants of the tubby-like protein 1 gene.Semantic proximity Read ↗

Tulp1 deficiency causes early-onset retinal degeneration through affecting ciliogenesis and activating ferroptosis in zebrafishSemantic proximity Read ↗

Early synaptic defects in tulp1-/- mice.Semantic proximity Read ↗

Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis.Semantic proximity Read ↗

Towards understanding the function of the tubby gene family in the retina.Semantic proximity Read ↗

Tubby proteins: the plot thickens.Semantic proximity Read ↗

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteinsSemantic proximity Read ↗

Rhodopsin Trafficking and Mistrafficking: Signals, Molecular Components, and Mechanisms.Semantic proximity Read ↗

TULP1 missense mutations cause variable retinal phenotypes and activation of the endoplasmic reticulum unfolded protein response pathway.Semantic proximity Read ↗

Biallelic Inactivating TUB Variants Cause Retinal Ciliopathy Impairing Biogenesis and the Structure of the Primary Cilium.Semantic proximity Read ↗

The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration.Semantic proximity Read ↗

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