Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tubby proteins: the plot thickens.

Nature reviews. Molecular cell biology - 1 Jan 2004

Carroll Kilpatrick, Gomez Carlos, Shapiro Lawrence

Abstract excerpt

The tubby mouse, which shows late-onset obesity and neurosensory deficits, arises from a mutation in the Tub gene. Tub shares homology with the genes for tubby-like proteins Tulp1, Tulp2 and Tulp3. Ablation of Tub, Tulp1 or Tulp3 causes disease phenotypes that are indicative of their importance in nervous-system function and development. Despite this importance, the biochemical functions of tubby-like proteins...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Embryonic and Fetal Development
Share to Eye Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Nervous System Diseases

Share to Obesity

Share to Point Mutation

Share to Proteins

Source

Identifiers

PMID: 14708010
DOI: 10.1038/nrm1278

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tubby proteins: the plot thickens.PMID 14708010Read ↗

The tubby-like proteins, a family with roles in neuronal development and function.Semantic proximity Read ↗

Retinal degeneration but not obesity is observed in null mutants of the tubby-like protein 1 gene.Semantic proximity Read ↗

Targeted deletion of the tub mouse obesity gene reveals that tubby is a loss-of-function mutation.Semantic proximity Read ↗

Prominent neuronal-specific tub gene expression in cellular targets of tubby mice mutation.Semantic proximity Read ↗

Unconventional secretion of tubby and tubby-like protein 1.Semantic proximity Read ↗

Thyroid hormone regulates the obesity gene tub.Semantic proximity Read ↗

C-terminally mutated tubby protein accumulates in aggresomes.Semantic proximity Read ↗

C. elegans tubby regulates life span and fat storage by two independent mechanisms.Semantic proximity Read ↗

Tubby domain superfamily protein is required for the formation of the 7S SNARE complex in Drosophila.Semantic proximity Read ↗

Towards understanding the function of the tubby gene family in the retina.Semantic proximity Read ↗

Microtubule-associated protein 1A is a modifier of tubby hearing (moth1).Semantic proximity Read ↗

Abnormal cholinergic and GABAergic vascular innervation in the hypothalamic arcuate nucleus of obese tub/tub mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.