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Article

Tubby proteins: the plot thickens.

Nature reviews. Molecular cell biology - 1 Jan 2004

Carroll Kilpatrick, Gomez Carlos, Shapiro Lawrence

Abstract excerpt

The tubby mouse, which shows late-onset obesity and neurosensory deficits, arises from a mutation in the Tub gene. Tub shares homology with the genes for tubby-like proteins Tulp1, Tulp2 and Tulp3. Ablation of Tub, Tulp1 or Tulp3 causes disease phenotypes that are indicative of their importance i...

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Source

Identifiers

PMID: 14708010
DOI: 10.1038/nrm1278

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14708010-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Tubby proteins: the plot thickens.PMID 14708010Read ↗

The tubby-like proteins, a family with roles in neuronal development and function.Semantic proximity Read ↗

Retinal degeneration but not obesity is observed in null mutants of the tubby-like protein 1 gene.Semantic proximity Read ↗

Targeted deletion of the tub mouse obesity gene reveals that tubby is a loss-of-function mutation.Semantic proximity Read ↗

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Thyroid hormone regulates the obesity gene tub.Semantic proximity Read ↗

C-terminally mutated tubby protein accumulates in aggresomes.Semantic proximity Read ↗

C. elegans tubby regulates life span and fat storage by two independent mechanisms.Semantic proximity Read ↗

Tubby domain superfamily protein is required for the formation of the 7S SNARE complex in Drosophila.Semantic proximity Read ↗

Towards understanding the function of the tubby gene family in the retina.Semantic proximity Read ↗

Microtubule-associated protein 1A is a modifier of tubby hearing (moth1).Semantic proximity Read ↗

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