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Article

A role for the Tubby-like protein 1 in rhodopsin transport.

Investigative ophthalmology & visual science - 1 Aug 2001

Hagstrom S A, Adamian M, Scimeca M, Pawlyk B S, Yue G, Li T

Abstract excerpt

PURPOSE: To test the hypothesis that a lack of Tubby-like protein 1 (TULP1) function causes aberrant transport of nascent rhodopsin and to examine the functional relationship between the homologous proteins TULP1 and Tubby by studying mice carrying combined mutations. METHODS: Subcellular localization of TULP1 and rhodopsin in photoreceptors was determined by immunofluorescence and by postembedding immunoelectron...

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Source

Identifiers

PMID: 11481257

Genes

TULP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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A role for the Tubby-like protein 1 in rhodopsin transport.PMID 11481257Read ↗

Drosophila king tubby (ktub) mediates light-induced rhodopsin endocytosis and retinal degeneration.Semantic proximity Read ↗

Early synaptic defects in tulp1-/- mice.Semantic proximity Read ↗

Retinal degeneration but not obesity is observed in null mutants of the tubby-like protein 1 gene.Semantic proximity Read ↗

TULP1 missense mutations cause variable retinal phenotypes and activation of the endoplasmic reticulum unfolded protein response pathway.Semantic proximity Read ↗

Tulp1 deficiency causes early-onset retinal degeneration through affecting ciliogenesis and activating ferroptosis in zebrafishSemantic proximity Read ↗

Tubby proteins: the plot thickens.Semantic proximity Read ↗

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteinsSemantic proximity Read ↗

Towards understanding the function of the tubby gene family in the retina.Semantic proximity Read ↗

Targeted deletion of the tub mouse obesity gene reveals that tubby is a loss-of-function mutation.Semantic proximity Read ↗

Ift172 conditional knock-out mice exhibit rapid retinal degeneration and protein trafficking defects.Semantic proximity Read ↗

<i>Ift172</i> conditional knockout mice exhibit rapid retinal degeneration and protein trafficking defectsSemantic proximity Read ↗

An allele of microtubule-associated protein 1A (Mtap1a) reduces photoreceptor degeneration in Tulp1 and Tub Mutant Mice.Semantic proximity Read ↗

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