Article
Prominent neuronal-specific tub gene expression in cellular targets of tubby mice mutation.
Human molecular genetics - 1 Sept 1998
Sahly I, Gogat K, Kobetz A, Marchant D, Menasche M, Castel M, Revah F, Dufier J, Guerre-Millo M, Abitbol M M
Abstract excerpt
The tubby strain of mice exhibits maturity-onset obesity and sensory deficits in vision and hearing. The mutated gene, tub , responsible for this phenotype was identified recently, but the function of the TUB protein has not been deduced from its amino acid sequence. This prompted us to undertake...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- Base Sequence
- Female
- Gene Expression Regulation, Developmental
- Hearing Disorders
- In Situ Hybridization
- Mice
- Mutation
- Neurons
- Obesity
- Oligonucleotide Probes
- Pregnancy
- Proteins
- Vision Disorders