Article
Protein stabilization: a common consequence of mutations in independently derived v-Myc alleles.
Oncogene - 9 Dec 1999
Gavine P R, Neil J C, Crouch D H
Abstract excerpt
Myc is overexpressed in many cancers as a result of gene rearrangement or amplification, but coding sequence changes which cluster in the N-terminal transactivation domain also appear to play a role in tumour progression. The prototypic v-Myc gene of MC29 virus differs from avian c-Myc by a series of mutations, including a change at a regulatory phosphorylation site within the mutational hotspot (thr-61) which is...
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