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Article

p53 Stabilization and Accumulation Induced by Human Vaccinia-Related Kinase 1

12 Nov 2004

Abstract excerpt

Variations in intracellular levels of p53 regulate many cellular functions and determine tumor susceptibility. Major mechanisms modulating p53 levels include phosphorylation and interaction of p53 with specific ubiquitin ligases that promote its degradation. N-terminal phosphorylation regulates the interaction of p53 with several regulatory molecules. Vaccinia-related kinase 1 (VRK1) is the prototype of a new...

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PMID: 15542844
DOI: 10.1128/mcb.24.23.10366-10380.2004

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