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Article

Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc.

The EMBO journal - 1 Feb 1999

Salghetti S E, Kim S Y, Tansey W P

Abstract excerpt

The human proto-oncogene c-myc encodes a highly unstable transcription factor that promotes cell proliferation. Although the extreme instability of Myc plays an important role in preventing its accumulation in normal cells, little is known about how Myc is targeted for rapid destruction. Here, we have investigated mechanisms regulating the stability of Myc. We show that Myc is destroyed by ubiquitin-mediated...

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Identifiers

PMID: 9927431
DOI: 10.1093/emboj/18.3.717
PMCID: PMC1171164

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Source receipt: pubmed, retrieved 7 Sept 2026.

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