Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc.

doi:10.1093/emboj/18.3.717

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Article

Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc.

The EMBO journal - 1 Feb 1999

Salghetti S E, Kim S Y, Tansey W P

Abstract excerpt

The human proto-oncogene c-myc encodes a highly unstable transcription factor that promotes cell proliferation. Although the extreme instability of Myc plays an important role in preventing its accumulation in normal cells, little is known about how Myc is targeted for rapid destruction. Here, we...

Topics

Animals
Cell Line
Cell Transformation, Neoplastic
DNA-Binding Proteins
Drug Stability
Endopeptidases
Genes, myc
Humans
Kruppel-Like Transcription Factors
Mice
Mutation
Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Mas

Proto-Oncogene Proteins c-myc

Recombinant Proteins

Saccharomyces cerevisiae

Transcription Factors

Ubiquitins

Source

Open in PubMed Open full text

Identifiers

PMID: 9927431
DOI: 10.1093/emboj/18.3.717
PMCID: PMC1171164

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9927431-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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