Article
Viral mutations enhance the Max binding properties of the vMyc b-HLH-LZ domain.
Nucleic acids research - 1 Jan 2005
Crouch D H, Fisher F, La Rocca S A, Goding C R, Gillespie D A F
Abstract excerpt
Interaction with Max via the helix-loop-helix/leucine zipper (HLH-LZ) domain is essential for Myc to function as a transcription factor. Myc is commonly upregulated in tumours, however, its activity can also be potentiated by virally derived mutations. vMyc, derived from the virus, MC29 gag-Myc, differs from its cellular counterpart by five amino acids. The N-terminal mutation stabilizes the protein, however, the...
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