Article
c-Myc hot spot mutations in lymphomas result in inefficient ubiquitination and decreased proteasome-mediated turnover.
Blood - 15 Mar 2000
Bahram F, von der Lehr N, Cetinkaya C, Larsson L G
Abstract excerpt
The c-myc proto-oncogene encodes a short-lived transcription factor that plays an important role in cell cycle regulation, differentiation and apoptosis. c-myc is often rearranged in tumors resulting in deregulated expression. In addition, mutations in the coding region of c-myc are frequently found in human lymphomas, a hot spot being the Thr58 phosphorylation site, a mutation shown to enhance the transforming...
Topics
- Burkitt Lymphoma
- Cysteine Endopeptidases
- Genes, myc
- Humans
- Lymphoma
- Multienzyme Complexes
- Mutation
- Mutation, Missense
- Phosphorylation
- Proline
- Proteasome Endopeptidase Complex
- Proto-Oncogene Mas
- Threonine
- Time Factors
- Tumor Cells, Cultured
- Ubiquitins