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Article

Evasion from proteasomal degradation by mutated Fos proteins expressed from FBJ-MSV and FBR-MSV osteosarcomatogenic retroviruses.

Biochemical pharmacology - 1 Sept 2002

Acquaviva Claire, Bossis Guillaume, Ferrara Patrizia, Brockly Frédérique, Jariel-Encontre Isabelle, Piechaczyk Marc

Abstract excerpt

c-Fos proto-oncoprotein is highly unstable, which is crucial for rapid gene expression shut-off and control of its intrinsic oncogenic potential. It is massively degraded by the proteasome in vivo in various situations. Although there is evidence that c-Fos can be ubiquitinylated in vitro, the unambiguous demonstration that ubiquitinylation is necessary for recognition and subsequent hydrolysis by the proteasome...

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Identifiers

PMID: 12213592
DOI: 10.1016/s0006-2952(02)01159-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evasion from proteasomal degradation by mutated Fos proteins expressed from FBJ-MSV and FBR-MSV osteosarcomatogenic retroviruses.PMID 12213592Read ↗

Degradation of cellular and viral Fos proteins.Semantic proximity Read ↗

c-Fos proto-oncoprotein is degraded by the proteasome independently of its own ubiquitinylation in vivo.Semantic proximity Read ↗

Identification of a C-terminal tripeptide motif involved in the control of rapid proteasomal degradation of c-Fos proto-oncoprotein during the G(0)-to-S phase transition.Semantic proximity Read ↗

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The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells.Semantic proximity Read ↗

Functional analyses of a human vascular tumor FOS variant identify a novel degradation mechanism and a link to tumorigenesisSemantic proximity Read ↗

Interplay of two functionally and structurally distinct domains of the c-fos AU-rich element specifies its mRNA-destabilizing function.Semantic proximity Read ↗

c-Fos induces chondrogenic tumor formation in immortalized human mesenchymal progenitor cellsSemantic proximity Read ↗

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Accumulated helix-destabilizing mutations in the leucine zipper of c-Fos leads to attenuation and temperature sensitivity of function.Semantic proximity Read ↗

5' untranslated sequences modulate rapid mRNA degradation mediated by 3' AU-rich element in v-/c-fos recombinants.Semantic proximity Read ↗

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