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Article

Nonparametric linkage and family-based association studies of a simulated complex disorder.

Genetic epidemiology - 1 Jan 1999

Koller D L, Balding J, Foroud T

Abstract excerpt

Affected sibling pairs are widely used to identify chromosomal regions harboring genetic loci underlying common disease. We explore the utility of nonparametric sibling pair and family-based association methods to search for disease susceptibility loci in simulated pedigree data for a qualitative disease trait. Logistic regression was used to model gene x gene and gene x environment interactions when significant...

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PMID: 10597504
DOI: 10.1002/gepi.13701707102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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