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Article

Nonparametric linkage and family-based association studies of a simulated complex disorder.

Genetic epidemiology - 1 Jan 1999

Koller D L, Balding J, Foroud T

Abstract excerpt

Affected sibling pairs are widely used to identify chromosomal regions harboring genetic loci underlying common disease. We explore the utility of nonparametric sibling pair and family-based association methods to search for disease susceptibility loci in simulated pedigree data for a qualitative disease trait. Logistic regression was used to model gene x gene and gene x environment interactions when significant...

Topics

Alleles
Environment
Epistasis, Genetic
Family
Genetic Linkage
Genetic Markers
Genetic Testing
Genotype
Humans
Linkage Disequilibrium
Lod Score
Logistic Models

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Genetic

Statistics, Nonparametric

Source

Identifiers

PMID: 10597504
DOI: 10.1002/gepi.13701707102

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-10597504-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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