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Article

Toward a methodology for evaluating DNA variants in nuclear families.

PloS one - 1 Jan 2021

Miller Dustin B, Robison Reid, Piccolo Stephen R

Abstract excerpt

The genetic underpinnings of most pediatric-cancer cases are unknown. Population-based studies use large sample sizes but have accounted for only a small proportion of the estimated heritability of pediatric cancers. Pedigree-based studies are infeasible for most human populations. One alternative is to collect genetic data from a single nuclear family and use inheritance patterns within the family to filter...

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Identifiers

PMID: 34624066
DOI: 10.1371/journal.pone.0258375
PMCID: PMC8500447

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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