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Article

A multi-SNP association test for complex diseases incorporating an optimal P-value threshold algorithm in nuclear families.

BMC genomics - 15 May 2015

Wang Yi-Ting, Sung Pei-Yuan, Lin Peng-Lin, Yu Ya-Wen, Chung Ren-Hua

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have become a common approach to identifying single nucleotide polymorphisms (SNPs) associated with complex diseases. As complex diseases are caused by the joint effects of multiple genes, while the effect of individual gene or SNP is modest, a method considering the joint effects of multiple SNPs can be more powerful than testing individual SNPs. The multi-SNP...

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PMID: 25975968
DOI: 10.1186/s12864-015-1620-3
PMCID: PMC4433014

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