Article
Identification of susceptibility loci for complex diseases in a case-control association study using the Genetic Analysis Workshop 14 dataset.
BMC genetics - 30 Dec 2005
Kerstann Kimberly F, Jacobs Kevin, Yang Xiaohong Rose, Bergen Andrew W, Goldin Lynn R, Goldstein Alisa M
Abstract excerpt
Although current methods in genetic epidemiology have been extremely successful in identifying genetic loci responsible for Mendelian traits, most common diseases do not follow simple Mendelian modes of inheritance. It is important to consider how our current methodologies function in the realm of complex diseases. The aim of this study was to determine the ability of conventional association methods to fine map...
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