Article
Identification of susceptibility loci contributing to a complex disease using conventional segregation, linkage, and association methods.
Genetic epidemiology - 1 Jan 1995
Falk C T, Ashley A, Lamb N, Sherman S L
Abstract excerpt
We set out to apply conventional analytic methods to a GAW data set of nuclear families with an oligogenic disease that has a population prevalence of 0.023. We chose methods generally applied to disorders with at least one major gene. Our approaches included: 1) complex segregation analysis unde...
Topics
- Alleles
- Case-Control Studies
- Chromosome Mapping
- Chromosomes, Human, Pair 1
- Chromosomes, Human, Pair 5
- Female
- Genes, Recessive
- Genetic Diseases, Inborn
- Genetic Predisposition to Disease
- Genetics, Population
- Haplotypes
- Humans
- Lod Score
- Male
- Models, Genetic
- Prevalence
- Risk Assessment