Article
A genome-wide search for susceptibility loci to human essential hypertension.
Hypertension (Dallas, Tex. : 1979) - 1 Jun 2000
Sharma P, Fatibene J, Ferraro F, Jia H, Monteith S, Brown C, Clayton D, O'Shaughnessy K, Brown M J
Abstract excerpt
We undertook a systematic search of the entire human genome with the affected sibling-pair model to identify major susceptibility loci to essential hypertension. Affected nuclear families (n=263) were recruited and divided according to definite or probable genetic contribution to hypertension depending on number of hypertensive siblings. The largest nuclear families were first screened with a set of...
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