Article
The impact of marker allele frequency misspecification in variance components quantitative trait locus analysis using sibship data.
Genetic epidemiology - 1 Jan 1999
Borecki I B, Province M A
Abstract excerpt
In cases where sibship data are collected for a quantitative trait locus (QTL) linkage study without access to parental genotypes, the proportion of genes shared identical by descent must be estimated using the marker allele frequencies. No systematic study has been conducted to date to evaluate the effect of misspecification of these frequencies on a test of quantitative trait linkage. Analysis of both simulated...
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