Article
The impact of genotyping error on family-based analysis of quantitative traits.
European journal of human genetics : EJHG - 1 Feb 2001
Abecasis G R, Cherny S S, Cardon L R
Abstract excerpt
Errors in genotyping can substantially influence the power to detect linkage using affected sib-pairs, but it is not clear what effect such errors have on quantitative trait analyses. Here we use Monte Carlo simulation to examine the influence of genotyping error on multipoint vs two-point analysis, variable map density, locus effect size and allele frequency in quantitative trait linkage and association studies...
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