Article
Effect of genotyping error in model-free linkage analysis using microsatellite or single-nucleotide polymorphism marker maps.
BMC genetics - 30 Dec 2005
Thompson Cheryl L, Baechle Dan, Lu Qing, Mathew George, Song Yeunjoo, Iyengar Sudha K, Gray-McGuire Courtney, Goddard Katrina A B
Abstract excerpt
Errors while genotyping are inevitable and can reduce the power to detect linkage. However, does genotyping error have the same impact on linkage results for single-nucleotide polymorphism (SNP) and microsatellite (MS) marker maps? To evaluate this question we detected genotyping errors that are consistent with Mendelian inheritance using large changes in multipoint identity-by-descent sharing in neighboring...
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