Effects of marker information on sib-pair linkage analysis of a rare disease.

doi:10.1002/gepi.1370120617

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Article

Effects of marker information on sib-pair linkage analysis of a rare disease.

Genetic epidemiology - 1 Jan 1995

Korczak J F, Pugh E W, Premkumar S, Guo X, Elston R C, Bailey-Wilson J E

Abstract excerpt

Model-free sib-pair linkage analysis was used to screen the GAW9-Problem 1 data set for evidence of linkage of a rare disease to any of 360 highly polymorphic marker loci. Negative regressions nominally significant at the alpha = 0.05 level were obtained for 44 markers; however all of these prove...

Topics

Alleles
Chromosome Mapping
Gene Frequency
Genetic Diseases, Inborn
Genetic Markers
Genetic Testing
Humans
Nuclear Family
Predictive Value of Tests
Regression Analysis

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