Article
The effect of genotyping error in sib-pair genomewide linkage scans depends crucially upon the method of analysis.
Journal of human genetics - 1 Jan 2005
Walters Kevin
Abstract excerpt
In genomewide linkage scans for complex diseases involving many loci with small genetic effects, it may be the case that no loci reach conventional statistical significance. A complementary method of evaluating linkage results, locus counting, may provide evidence for the existence of a number of genetic loci in these cases. Sib-pair study designs are often used in genomewide linkage scans, but because all...
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