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Article

Incorrect specification of marker allele frequencies: effects on linkage analysis.

American journal of human genetics - 1 Jun 1993

Freimer N B, Sandkuijl L A, Blower S M

Abstract excerpt

Most current linkage analyses make use of highly polymorphic DNA markers. Assigning correct allele frequencies for these markers may be extremely difficult in particular study populations. Designation of erroneous frequencies may result in false-positive evidence for linkage, as well as in failure to correctly exclude linkage. These effects are most pronounced in small pedigrees with key individuals unavailable...

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PMID: 8503444
PMCID: PMC1682284

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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