Article
Incorrect specification of marker allele frequencies: effects on linkage analysis.
American journal of human genetics - 1 Jun 1993
Freimer N B, Sandkuijl L A, Blower S M
Abstract excerpt
Most current linkage analyses make use of highly polymorphic DNA markers. Assigning correct allele frequencies for these markers may be extremely difficult in particular study populations. Designation of erroneous frequencies may result in false-positive evidence for linkage, as well as in failur...
Topics
- Alleles
- Computer Simulation
- False Positive Reactions
- Female
- Gene Frequency
- Genetic Linkage
- Genetic Markers
- Humans
- Male
- Pedigree