Article
Linkage disequilibrium inflates type I error rates in multipoint linkage analysis when parental genotypes are missing.
Human heredity - 1 Jan 2005
Boyles Abee L, Scott William K, Martin Eden R, Schmidt Silke, Li Yi-Ju, Ashley-Koch Allison, Bass Meredyth P, Schmidt Michael, Pericak-Vance Margaret A, Speer Marcy C, Hauser Elizabeth R
Abstract excerpt
OBJECTIVES: Describe the inflation in nonparametric multipoint LOD scores due to inter-marker linkage disequilibrium (LD) across many markers with varied allele frequencies. METHOD: Using simulated two-generation families with and without parents, we conducted nonparametric multipoint linkage analysis with 2 to 10 markers with minor allele frequencies (MAF) of 0.5 and 0.1. RESULTS: Misspecification of population...
Topics
- Computer Simulation
- False Positive Reactions
- Gene Frequency
- Genetic Linkage
- Genetic Markers
- Genotype
- Humans
- Linkage Disequilibrium
- Lod Score
- Nuclear Family
- Parents
- Statistics, Nonparametric