Article
Allele frequency misspecification: effect on power and Type I error of model-dependent linkage analysis of quantitative traits under random ascertainment.
BMC genetics - 20 Apr 2006
Mandal Diptasri M, Sorant Alexa J M, Atwood Larry D, Wilson Alexander F, Bailey-Wilson Joan E
Abstract excerpt
BACKGROUND: Studies of model-based linkage analysis show that trait or marker model misspecification leads to decreasing power or increasing Type I error rate. An increase in Type I error rate is seen when marker related parameters (e.g., allele frequencies) are misspecified and ascertainment is through the trait, but lod-score methods are expected to be robust when ascertainment is random (as is often the case...
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