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Article

The effect of long-range loop-loop interactions on folding of the Tetrahymena self-splicing RNA.

Journal of molecular biology - 10 Dec 1999

Pan J, Woodson S A

Abstract excerpt

Bas?e-pairing between the terminal loops of helices P2.1 and P9.1a (P13) and P2 and P5c (P14) stabilize the folded structure of the Tetrahymena group I intron. Using native gel electrophoresis to analyze the folding kinetics of a natural pre-RNA containing the Tetrahymena intron, we show that P13 and P14 are the only native loop-loop interactions among six possible combinations. Other base-pairing interactions of...

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Source

Identifiers

PMID: 10588899
DOI: 10.1006/jmbi.1999.3298

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The effect of long-range loop-loop interactions on folding of the Tetrahymena self-splicing RNA.PMID 10588899Read ↗

The long-range P3 helix of the Tetrahymena ribozyme is disrupted during folding between the native and misfolded conformations.Semantic proximity Read ↗

Folding pathways of the Tetrahymena ribozyme.Semantic proximity Read ↗

Multiple unfolding events during native folding of the Tetrahymena group I ribozyme.Semantic proximity Read ↗

Folding mechanism of the Tetrahymena ribozyme P4-P6 domain.Semantic proximity Read ↗

Role of a conserved J8/7 X P4 base-triple in the Tetrahymena ribozyme.Semantic proximity Read ↗

Energetics and cooperativity of tertiary hydrogen bonds in RNA structure.Semantic proximity Read ↗

Two major tertiary folding transitions of the Tetrahymena catalytic RNA.Semantic proximity Read ↗

Fast folding mutants of the Tetrahymena group I ribozyme reveal a rugged folding energy landscape.Semantic proximity Read ↗

An RNA internal loop acts as a hinge to facilitate ribozyme folding and catalysis.Semantic proximity Read ↗

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Comparison of crystal structure interactions and thermodynamics for stabilizing mutations in the Tetrahymena ribozyme.Semantic proximity Read ↗

Enhanced specificity against misfolding in a thermostable mutant of the Tetrahymena ribozyme.Semantic proximity Read ↗

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