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Article

Comparison of crystal structure interactions and thermodynamics for stabilizing mutations in the Tetrahymena ribozyme.

RNA (New York, N.Y.) - 1 Mar 2006

Guo Feng, Gooding Anne R, Cech Thomas R

Abstract excerpt

Although general mechanisms of RNA folding and catalysis have been elucidated, little is known about how ribozymes achieve structural stability at high temperature. A previous in vitro evolution experiment identified a small number of mutations that significantly increase the thermostability of the tertiary structure of the Tetrahymena ribozyme. Because we also determined the crystal structure of this...

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Identifiers

PMID: 16431981
DOI: 10.1261/rna.2198206
PMCID: PMC1383578

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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