Article
Two major tertiary folding transitions of the Tetrahymena catalytic RNA.
The EMBO journal - 1 Jun 1994
Laggerbauer B, Murphy F L, Cech T R
Abstract excerpt
The L-21 Tetrahymena ribozyme, an RNA molecule with sequence-specific endoribonuclease activity derived from a self-splicing group I intron, provides a model system for studying the RNA folding problem. A 160 nucleotide, independently folding domain of tertiary structure (the P4-P6 domain) compri...
Topics
- Animals
- Base Sequence
- Cations, Divalent
- Edetic Acid
- Ferrous Compounds
- Kinetics
- Magnesium
- Models, Genetic
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Point Mutation
- RNA, Catalytic
- RNA, Protozoan
- Tetrahymena
- Transcription, Genetic