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Article

Two major tertiary folding transitions of the Tetrahymena catalytic RNA.

The EMBO journal - 1 Jun 1994

Laggerbauer B, Murphy F L, Cech T R

Abstract excerpt

The L-21 Tetrahymena ribozyme, an RNA molecule with sequence-specific endoribonuclease activity derived from a self-splicing group I intron, provides a model system for studying the RNA folding problem. A 160 nucleotide, independently folding domain of tertiary structure (the P4-P6 domain) comprises about half of the ribozyme. We now apply Fe(II)-EDTA cleavage to mutants of the ribozyme to explore the role of...

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Identifiers

PMID: 8013466
DOI: 10.1002/j.1460-2075.1994.tb06557.x
PMCID: PMC395141

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Two major tertiary folding transitions of the Tetrahymena catalytic RNA.PMID 8013466Read ↗

Folding mechanism of the Tetrahymena ribozyme P4-P6 domain.Semantic proximity Read ↗

The long-range P3 helix of the Tetrahymena ribozyme is disrupted during folding between the native and misfolded conformations.Semantic proximity Read ↗

Fast folding of a ribozyme by stabilizing core interactions: evidence for multiple folding pathways in RNA.Semantic proximity Read ↗

Folding pathways of the Tetrahymena ribozyme.Semantic proximity Read ↗

An RNA internal loop acts as a hinge to facilitate ribozyme folding and catalysis.Semantic proximity Read ↗

Multiple unfolding events during native folding of the Tetrahymena group I ribozyme.Semantic proximity Read ↗

The effect of long-range loop-loop interactions on folding of the Tetrahymena self-splicing RNA.Semantic proximity Read ↗

Role of a conserved J8/7 X P4 base-triple in the Tetrahymena ribozyme.Semantic proximity Read ↗

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Fast folding mutants of the Tetrahymena group I ribozyme reveal a rugged folding energy landscape.Semantic proximity Read ↗

An early transition state for folding of the P4-P6 RNA domain.Semantic proximity Read ↗

Structural basis of the enhanced stability of a mutant ribozyme domain and a detailed view of RNA--solvent interactions.Semantic proximity Read ↗

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