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Article

Enhanced specificity against misfolding in a thermostable mutant of the Tetrahymena ribozyme.

Biochemistry - 8 Feb 2011

Wan Yaqi, Russell Rick

Abstract excerpt

Structured RNAs encode native conformations that are more stable than the vast ensembles of alternative conformations, but how this specificity is evolved is incompletely understood. Here we show that a variant of the Tetrahymena group I intron ribozyme that was generated previously by in vitro selection for enhanced thermostability also displays modestly enhanced specificity against a stable misfolded structure...

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Identifiers

PMID: 21174447
DOI: 10.1021/bi101467q
PMCID: PMC3227551

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Enhanced specificity against misfolding in a thermostable mutant of the Tetrahymena ribozyme.PMID 21174447Read ↗

Evolution of Tetrahymena ribozyme mutants with increased structural stability.Semantic proximity Read ↗

Multiple unfolding events during native folding of the Tetrahymena group I ribozyme.Semantic proximity Read ↗

The long-range P3 helix of the Tetrahymena ribozyme is disrupted during folding between the native and misfolded conformations.Semantic proximity Read ↗

Folding pathways of the Tetrahymena ribozyme.Semantic proximity Read ↗

Comparison of crystal structure interactions and thermodynamics for stabilizing mutations in the Tetrahymena ribozyme.Semantic proximity Read ↗

Fast folding mutants of the Tetrahymena group I ribozyme reveal a rugged folding energy landscape.Semantic proximity Read ↗

Fast folding of a ribozyme by stabilizing core interactions: evidence for multiple folding pathways in RNA.Semantic proximity Read ↗

Facilitation of group I splicing in vivo: misfolding of the Tetrahymena IVS and the role of ribosomal RNA exons.Semantic proximity Read ↗

Concerted kinetic folding of a multidomain ribozyme with a disrupted loop-receptor interaction.Semantic proximity Read ↗

The effect of long-range loop-loop interactions on folding of the Tetrahymena self-splicing RNA.Semantic proximity Read ↗

Mutations in the Tetrahymena ribozyme internal guide sequence: effects on docking of the P1 helix into the catalytic core and correlation with catalytic activity.Semantic proximity Read ↗

Structural basis of the enhanced stability of a mutant ribozyme domain and a detailed view of RNA--solvent interactions.Semantic proximity Read ↗

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