Article
Fast folding mutants of the Tetrahymena group I ribozyme reveal a rugged folding energy landscape.
Journal of molecular biology - 28 Aug 1998
Rook M S, Treiber D K, Williamson J R
Abstract excerpt
A model for the kinetic folding pathway of the Tetrahymena ribozyme has been proposed where the two main structural domains, P4-P6 and P3-P7, form in a hierarchical manner with P4-P6 forming first and P3-P7 folding on the minute timescale. Recent studies in our laboratory identified a set of muta...
Topics
- Animals
- Base Sequence
- Catalysis
- Kinetics
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Nucleic Acid Hybridization
- Protein Folding
- RNA, Catalytic
- Temperature
- Tetrahymena
- Thermodynamics
- Urea