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Article

Fast folding mutants of the Tetrahymena group I ribozyme reveal a rugged folding energy landscape.

Journal of molecular biology - 28 Aug 1998

Rook M S, Treiber D K, Williamson J R

Abstract excerpt

A model for the kinetic folding pathway of the Tetrahymena ribozyme has been proposed where the two main structural domains, P4-P6 and P3-P7, form in a hierarchical manner with P4-P6 forming first and P3-P7 folding on the minute timescale. Recent studies in our laboratory identified a set of mutations that accelerate P3-P7 formation, and all of these mutations appear to destabilize a native-like kinetic trap. To...

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Source

Identifiers

PMID: 9710534
DOI: 10.1006/jmbi.1998.1960

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Fast folding mutants of the Tetrahymena group I ribozyme reveal a rugged folding energy landscape.PMID 9710534Read ↗

Folding pathways of the Tetrahymena ribozyme.Semantic proximity Read ↗

Multiple unfolding events during native folding of the Tetrahymena group I ribozyme.Semantic proximity Read ↗

Kinetic intermediates trapped by native interactions in RNA folding.Semantic proximity Read ↗

Fast folding of a ribozyme by stabilizing core interactions: evidence for multiple folding pathways in RNA.Semantic proximity Read ↗

The long-range P3 helix of the Tetrahymena ribozyme is disrupted during folding between the native and misfolded conformations.Semantic proximity Read ↗

Folding mechanism of the Tetrahymena ribozyme P4-P6 domain.Semantic proximity Read ↗

Visualizing the formation of an RNA folding intermediate through a fast highly modular secondary structure switch.Semantic proximity Read ↗

Perturbation of the hierarchical folding of a large RNA by the destabilization of its Scaffold's tertiary structure.Semantic proximity Read ↗

An early transition state for folding of the P4-P6 RNA domain.Semantic proximity Read ↗

Enhanced specificity against misfolding in a thermostable mutant of the Tetrahymena ribozyme.Semantic proximity Read ↗

Concerted kinetic folding of a multidomain ribozyme with a disrupted loop-receptor interaction.Semantic proximity Read ↗

The effect of long-range loop-loop interactions on folding of the Tetrahymena self-splicing RNA.Semantic proximity Read ↗

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