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Article

Fast folding of a ribozyme by stabilizing core interactions: evidence for multiple folding pathways in RNA.

Journal of molecular biology - 11 Feb 2000

Pan J, Deras M L, Woodson S A

Abstract excerpt

Folding of the Tetrahymena ribozyme under physiological conditions in vitro is limited by slow conversion of long-lived intermediates to the active structure. These intermediates arise because the most stable domain of the ribozyme folds 10-50 times more rapidly than the core region containing helix P3. Native gel electrophoresis and time-resolved X-ray-dependent hydroxyl radical cleavage revealed that mutations...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10656822
DOI: 10.1006/jmbi.1999.3439

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fast folding of a ribozyme by stabilizing core interactions: evidence for multiple folding pathways in RNA.PMID 10656822Read ↗

Folding pathways of the Tetrahymena ribozyme.Semantic proximity Read ↗

The long-range P3 helix of the Tetrahymena ribozyme is disrupted during folding between the native and misfolded conformations.Semantic proximity Read ↗

Multiple unfolding events during native folding of the Tetrahymena group I ribozyme.Semantic proximity Read ↗

Folding mechanism of the Tetrahymena ribozyme P4-P6 domain.Semantic proximity Read ↗

Fast folding mutants of the Tetrahymena group I ribozyme reveal a rugged folding energy landscape.Semantic proximity Read ↗

Two major tertiary folding transitions of the Tetrahymena catalytic RNA.Semantic proximity Read ↗

Evolution of Tetrahymena ribozyme mutants with increased structural stability.Semantic proximity Read ↗

Kinetic intermediates trapped by native interactions in RNA folding.Semantic proximity Read ↗

Comparison of crystal structure interactions and thermodynamics for stabilizing mutations in the Tetrahymena ribozyme.Semantic proximity Read ↗

Tertiary interactions determine the accuracy of RNA folding.Semantic proximity Read ↗

Enhanced specificity against misfolding in a thermostable mutant of the Tetrahymena ribozyme.Semantic proximity Read ↗

An RNA internal loop acts as a hinge to facilitate ribozyme folding and catalysis.Semantic proximity Read ↗

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