Article
An RNA internal loop acts as a hinge to facilitate ribozyme folding and catalysis.
RNA (New York, N.Y.) - 1 Aug 1997
Szewczak A A, Cech T R
Abstract excerpt
RNA molecules commonly consist of helical regions separated by internal loops, and in many cases these internal loops have been found to assume stable structures. We have examined the function and dynamics of an internal loop, J5/5a, that joins the two halves of the P4-P6 domain of the Tetrahymen...
Topics
- Base Sequence
- Binding Sites
- Edetic Acid
- Electrophoresis
- Free Radical Scavengers
- Introns
- Iron
- Kinetics
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- RNA, Catalytic