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Article

An RNA internal loop acts as a hinge to facilitate ribozyme folding and catalysis.

RNA (New York, N.Y.) - 1 Aug 1997

Szewczak A A, Cech T R

Abstract excerpt

RNA molecules commonly consist of helical regions separated by internal loops, and in many cases these internal loops have been found to assume stable structures. We have examined the function and dynamics of an internal loop, J5/5a, that joins the two halves of the P4-P6 domain of the Tetrahymena self-splicing group I intron. P4-P6 RNAs with mutations in the J5/5a region showed nondenaturing gel electrophoretic...

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Identifiers

PMID: 9257643
PMCID: PMC1369529

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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An RNA internal loop acts as a hinge to facilitate ribozyme folding and catalysis.PMID 9257643Read ↗

Two major tertiary folding transitions of the Tetrahymena catalytic RNA.Semantic proximity Read ↗

Folding mechanism of the Tetrahymena ribozyme P4-P6 domain.Semantic proximity Read ↗

The long-range P3 helix of the Tetrahymena ribozyme is disrupted during folding between the native and misfolded conformations.Semantic proximity Read ↗

Multiple unfolding events during native folding of the Tetrahymena group I ribozyme.Semantic proximity Read ↗

The effect of long-range loop-loop interactions on folding of the Tetrahymena self-splicing RNA.Semantic proximity Read ↗

Fast folding of a ribozyme by stabilizing core interactions: evidence for multiple folding pathways in RNA.Semantic proximity Read ↗

New loop-loop tertiary interactions in self-splicing introns of subgroup IC and ID: a complete 3D model of the Tetrahymena thermophila ribozyme.Semantic proximity Read ↗

Folding pathways of the Tetrahymena ribozyme.Semantic proximity Read ↗

Alternative secondary structures in the 5' exon affect both forward and reverse self-splicing of the Tetrahymena intervening sequence RNA.Semantic proximity Read ↗

An early transition state for folding of the P4-P6 RNA domain.Semantic proximity Read ↗

Mutations in the Tetrahymena ribozyme internal guide sequence: effects on docking of the P1 helix into the catalytic core and correlation with catalytic activity.Semantic proximity Read ↗

Structural basis of the enhanced stability of a mutant ribozyme domain and a detailed view of RNA--solvent interactions.Semantic proximity Read ↗

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