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Article

Rolling circle amplification of DNA immobilized on solid surfaces and its application to multiplex mutation detection.

Genetic analysis : biomolecular engineering - 1 Apr 1999

Hatch A, Sano T, Misasi J, Smith C L

Abstract excerpt

A new method of amplifying short DNA molecules immobilized on a solid support has been developed. This method uses a solid-phase rolling circle replication reaction, termed rolling circle amplification (RCA). The probe consists of a single-stranded DNA primer anchored at the 5' terminus to a solid support and a single stranded DNA template hybridized to the immobilized primer. Here, DNA ligase was used to...

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Identifiers

PMID: 10191983
DOI: 10.1016/s1050-3862(98)00014-x

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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