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Precision discrimination of single nucleotide polymorphisms via chemically engineered PNA-mediated padlock probe assembly and rolling circle amplification.

Analytica chimica acta - 22 Aug 2026

Zhao Yang, Wu Shuyao, Yuan Xiaojun, Zhao Chao

Abstract excerpt

Highly sensitive and specific detection of single nucleotide polymorphisms (SNPs) in genomic DNA is of great significance in disease diagnosis and personalized medicine. Here, we developed a fluorescent method for highly specific detection of SNPs in mixed-sequence KRAS double-stranded DNA (dsDNA) under physiological conditions by combining peptide nucleic acid (PNA)-directed padlock probe assembly with rolling...

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DNA
KRAS gene
Nucleic Acid Amplification Techniques
Nucleic Acid Hybridization
Peptide Nucleic Acids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Proto-Oncogene Proteins p21(ras)

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Identifiers

PMID: 42219641
DOI: 10.1016/j.aca.2026.345660

Genes

KRAS
MB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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