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Article

Structural rearrangements underlying ligand-gating in Kir channels.

Nature communications - 10 Jan 2012

Wang Shizhen, Lee Sun-Joo, Heyman Sarah, Enkvetchakul Decha, Nichols Colin G

Abstract excerpt

Inward rectifier potassium (Kir) channels are physiologically regulated by a wide range of ligands that all act on a common gate, although structural details of gating are unclear. Here we show, using small molecule fluorescent probes attached to introduced cysteines, the molecular motions associated with gating of KirBac1.1 channels. The accessibility of the probes indicates a major barrier to fluorophore entry...

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Identifiers

PMID: 22233627
DOI: 10.1038/ncomms1625
PMCID: PMC4277880

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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