Article
Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction.
Proceedings of the National Academy of Sciences of the United States of America - 23 Nov 1999
Wang T F, Kleckner N, Hunter N
Abstract excerpt
The yeast genome encodes four proteins (Pms1 and Mlh1-3) homologous to the bacterial mismatch repair component, MutL. Using two hybrid-interaction and coimmunoprecipitation studies, we show that these proteins can form only three types of complexes in vivo. Mlh1 is the common component of all three complexes, interacting with Pms1, Mlh2, and Mlh3, presumptively as heterodimers. The phenotypes of single deletion...
Topics
- Adaptor Proteins, Signal Transducing
- Adenosine Triphosphatases
- Animals
- Bacterial Proteins
- Base Pair Mismatch
- COS Cells
- Carrier Proteins
- DNA Repair
- Escherichia coli Proteins
- Fungal Proteins