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Article

Distinct regulation of Mlh1p heterodimers in meiosis and mitosis in Saccharomyces cerevisiae.

Genetics - 1 Jun 2010

Cotton Victoria E, Hoffmann Eva R, Borts Rhona H

Abstract excerpt

Mlh1p forms three heterodimers that are important for mismatch repair (Mlh1p/Pms1p), crossing over during meiosis (Mlh1p/Mlh3p), and channeling crossover events into a specific pathway (Mlh1p/Mlh2p). All four proteins contain highly conserved ATPase domains and Pms1p has endonuclease activity. Studies of the functional requirements for Mlh1p/Pms1p in Saccharomyces cerevisae revealed an asymmetric contribution of...

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Identifiers

PMID: 20382827
DOI: 10.1534/genetics.110.116806
PMCID: PMC2881129

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Distinct regulation of Mlh1p heterodimers in meiosis and mitosis in Saccharomyces cerevisiae.PMID 20382827Read ↗

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