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Article

DNA binding by yeast Mlh1 and Pms1: implications for DNA mismatch repair.

Nucleic acids research - 15 Apr 2003

Hall Mark C, Shcherbakova Polina V, Fortune John M, Borchers Christoph H, Dial J Michael, Tomer Kenneth B, Kunkel Thomas A

Abstract excerpt

The yeast Mlh1-Pms1 heterodimer required for mismatch repair (MMR) binds to DNA. Here we map DNA binding to N-terminal fragments of Mlh1 and Pms1. We demonstrate that Mlh1 and Pms1 N-terminal domains (NTDs) independently bind to double-stranded and single-stranded DNA, in the absence of dimerization and with different affinities. Full-length Mlh1p alone, which can homodimerize, also binds to DNA. Substituting...

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Identifiers

PMID: 12682353
DOI: 10.1093/nar/gkg324
PMCID: PMC153752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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