Article

MSH4 acts in conjunction with MLH1 during mammalian meiosis

2000-08-01

Abstract excerpt

MSH4 is a meiosis-specific MutS homolog. In yeast, it is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. MLH1 (MutL homolog 1) facilitates both mismatch repair and crossing over during meiosis in yeast. Germ-line mutations in the MLH1 human gene are responsible for hereditary nonpolyposis cancer, but the analysis of MLH1-deficient mice has revealed that MLH1 is...

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Literature Corpus work: f13ba715-676e-574c-85d2-f4d198e36ff3
DOI: 10.1096/fj.14.11.1539

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