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Article

mlh3 mutations in baker's yeast alter meiotic recombination outcomes by increasing noncrossover events genome-wide.

PLoS genetics - 1 Aug 2017

Al-Sweel Najla, Raghavan Vandana, Dutta Abhishek, Ajith V P, Di Vietro Luigi, Khondakar Nabila, Manhart Carol M, Surtees Jennifer A, Nishant K T, Alani Eric

Abstract excerpt

Mlh1-Mlh3 is an endonuclease hypothesized to act in meiosis to resolve double Holliday junctions into crossovers. It also plays a minor role in eukaryotic DNA mismatch repair (MMR). To understand how Mlh1-Mlh3 functions in both meiosis and MMR, we analyzed in baker's yeast 60 new mlh3 alleles. Five alleles specifically disrupted MMR, whereas one (mlh3-32) specifically disrupted meiotic crossing over. Mlh1-mlh3...

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Identifiers

PMID: 28827832
DOI: 10.1371/journal.pgen.1006974
PMCID: PMC5578695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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