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Coordinated and Independent Roles for MLH Subunits in DNA Repair

20 Apr 2021

Abstract excerpt

The MutL family of DNA mismatch repair proteins (MMR) acts to maintain genomic integrity in somatic and meiotic cells. In baker's yeast, the MutL homolog (MLH) MMR proteins form three heterodimeric complexes, MLH1-PMS1, MLH1-MLH2, and MLH1-MLH3. The recent discovery of human PMS2 (homolog of baker's yeast PMS1) and MLH3 acting independently of human MLH1 in the repair of somatic double-strand breaks questions the...

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PMID: 33923939
DOI: 10.3390/cells10040948

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Coordinated and Independent Roles for MLH Subunits in DNA RepairPMID 33923939Read ↗

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