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Article

Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene.

Molecular and cellular biology - 1 Jan 1994

Prolla T A, Christie D M, Liskay R M

Abstract excerpt

We have identified a new Saccharomyces cerevisiae gene, MLH1 (mutL homolog), that encodes a predicted protein product with sequence similarity to DNA mismatch repair proteins of bacteria (MutL and HexB) and S. cerevisiae yeast (PMS1). Disruption of the MLH1 gene results in elevated spontaneous mutation rates during vegetative growth as measured by forward mutation to canavanine resistance and reversion of the...

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Source

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Identifiers

PMID: 8264608
DOI: 10.1128/mcb.14.1.407-415.1994
PMCID: PMC358390

Genes

MLH1
PMS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene.PMID 8264608Read ↗

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Mlh1 is unique among mismatch repair proteins in its ability to promote crossing-over during meiosis.Semantic proximity Read ↗

Systematic mutagenesis of the Saccharomyces cerevisiae MLH1 gene reveals distinct roles for Mlh1p in meiotic crossing over and in vegetative and meiotic mismatch repair.Semantic proximity Read ↗

A role for the MutL homologue MLH2 in controlling heteroduplex formation and in regulating between two different crossover pathways in budding yeast.Semantic proximity Read ↗

Mutator phenotypes conferred by MLH1 overexpression and by heterozygosity for mlh1 mutations.Semantic proximity Read ↗

Analysis of conditional mutations in the Saccharomyces cerevisiae MLH1 gene in mismatch repair and in meiotic crossing over.Semantic proximity Read ↗

Saccharomyces cerevisiae MutLα Is a Mismatch Repair EndonucleaseSemantic proximity Read ↗

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Negative epistasis between natural variants of the Saccharomyces cerevisiae MLH1 and PMS1 genes results in a defect in mismatch repair.Semantic proximity Read ↗

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Interaction between mismatch repair and genetic recombination in Saccharomyces cerevisiae.Semantic proximity Read ↗

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