Article
Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene.
Molecular and cellular biology - 1 Jan 1994
Prolla T A, Christie D M, Liskay R M
Abstract excerpt
We have identified a new Saccharomyces cerevisiae gene, MLH1 (mutL homolog), that encodes a predicted protein product with sequence similarity to DNA mismatch repair proteins of bacteria (MutL and HexB) and S. cerevisiae yeast (PMS1). Disruption of the MLH1 gene results in elevated spontaneous mu...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- Base Sequence
- Cloning, Molecular
- DNA Repair
- DNA, Fungal
- Fungal Proteins
- Genes, Bacterial
- Genes, Fungal
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Restriction Mapping
- Saccharomyces cerevisiae
- Sequence Homology, Amino Acid