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Article

Mlh1 is unique among mismatch repair proteins in its ability to promote crossing-over during meiosis.

Genes & development - 15 Jun 1997

Hunter N, Borts R H

Abstract excerpt

In eukaryotes, homologs of the bacterial MutS and MutL proteins function in DNA mismatch repair and recombination pathways. The mutL homolog MLH1 is required for nuclear mismatch repair. Previously, cytological analysis of MLH1-deficient mice has implied a role for Mlh1 in crossing-over during meiosis. Here we demonstrate that Saccharomyces cerevisiae diploids containing a deletion of MLH1 have reduced...

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Source

Identifiers

PMID: 9203583
DOI: 10.1101/gad.11.12.1573

Genes

MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mlh1 is unique among mismatch repair proteins in its ability to promote crossing-over during meiosis.PMID 9203583Read ↗

Systematic mutagenesis of the Saccharomyces cerevisiae MLH1 gene reveals distinct roles for Mlh1p in meiotic crossing over and in vegetative and meiotic mismatch repair.Semantic proximity Read ↗

Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction.Semantic proximity Read ↗

A role for the MutL homologue MLH2 in controlling heteroduplex formation and in regulating between two different crossover pathways in budding yeast.Semantic proximity Read ↗

Analysis of conditional mutations in the Saccharomyces cerevisiae MLH1 gene in mismatch repair and in meiotic crossing over.Semantic proximity Read ↗

Coordinated and Independent Roles for MLH Subunits in DNA RepairSemantic proximity Read ↗

Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over.Semantic proximity Read ↗

MSH4 acts in conjunction with MLH1 during mammalian meiosisSemantic proximity Read ↗

Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene.Semantic proximity Read ↗

MSH4 acts in conjunction with MLH1 during mammalian meiosisSemantic proximity Read ↗

MSH5, a novel MutS homolog, facilitates meiotic reciprocal recombination between homologs in Saccharomyces cerevisiae but not mismatch repair.Semantic proximity Read ↗

Genetic analysis of mlh3 mutations reveals interactions between crossover promoting factors during meiosis in baker's yeast.Semantic proximity Read ↗

Competing crossover pathways act during meiosis in Saccharomyces cerevisiae.Semantic proximity Read ↗

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