Article
Mlh1 is unique among mismatch repair proteins in its ability to promote crossing-over during meiosis.
Genes & development - 15 Jun 1997
Hunter N, Borts R H
Abstract excerpt
In eukaryotes, homologs of the bacterial MutS and MutL proteins function in DNA mismatch repair and recombination pathways. The mutL homolog MLH1 is required for nuclear mismatch repair. Previously, cytological analysis of MLH1-deficient mice has implied a role for Mlh1 in crossing-over during me...
Topics
- Adaptor Proteins, Signal Transducing
- Adenosine Triphosphatases
- Animals
- Bacterial Proteins
- Base Sequence
- Crossing Over, Genetic
- DNA Primers
- DNA Repair
- DNA-Binding Proteins
- Escherichia coli
- Escherichia coli Proteins
- Fungal Proteins
- Genotype
- Karyotyping
- Meiosis
- Mice
- Models, Genetic
- Molecular Sequence Data