Article
A role for the MutL homologue MLH2 in controlling heteroduplex formation and in regulating between two different crossover pathways in budding yeast.
Cytogenetic and genome research - 1 Jan 2004
Abdullah M F F, Hoffmann E R, Cotton V E, Borts R H
Abstract excerpt
BACKGROUND AND AIMS: Mismatch repair proteins play important roles during meiotic recombination in the budding yeast Saccharomyces cerevisiae and most eukaryotic organisms studied to date. To study the functions of the mismatch repair protein Mlh2p in meiosis, we constructed mlh2Delta strains and measured rates of crossing over, gene conversion, post-meiotic segregation and spore viability. We also analysed...
Topics
- Adaptor Proteins, Signal Transducing
- Alleles
- Cell Survival
- Chromosome Segregation
- Crossing Over, Genetic
- DNA-Binding Proteins
- Endonucleases
- Exodeoxyribonucleases
- Fungal Proteins
- Gene Conversion