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Article

In vivo radiosensitizing effect of the adenovirus E1A gene in murine and human malignant tumors.

International journal of oncology - 1 Dec 1999

Martin-Duque P, Sánchez-Prieto R, Romero J, Martinez-Lamparero A, Cebrian-Sagarriga S, Guinea-Viniegra J, Dominguez C, Lleonart M, Cano A, Quintanilla M, Ramón Y Cajal S

Abstract excerpt

The adenovirus E1A gene is a potent inducer of chemosensitivity and radiosensitivity through p53-dependent and independent mechanisms. We have studied the sensitivity of murine (MSC11A5, a sarcomatoid epidermoid carcinoma) and human (HeLa, human cervix carcinoma) E1A-expressing tumors, in vivo, after treatment with cisplatin or gamma-irradiation. In athymic mice, half-body irradiation was performed in an AECL...

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Identifiers

PMID: 10568823
DOI: 10.3892/ijo.15.6.1163

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