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Article

In vivo influence of p53 status on proliferation and chemoradiosensitivity in non-small-cell lung cancer.

Journal of cancer research and clinical oncology - 1 Jan 1998

Perdomo J A, Naomoto Y, Haisa M, Fujiwara T, Hamada M, Yasuoka Y, Tanaka N

Abstract excerpt

Alteration of the p53 gene product is a frequent event in the progression of lung cancer. However, its importance to proliferation and response to chemoradiotherapy remains unclear. Thus, to assess its influence directly in vivo, we implanted into nude mice two kinds of human non-small-cell lung cancer (NSCLC) cells: H226br having a homozygous gene mutation in p53 (mt-p53) and H226b with intact p53 (wt-p53). We...

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Identifiers

PMID: 9498829
DOI: 10.1007/s004320050127

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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