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Markedly Enhanced Cytolysis by <i>E1B-19kD</i> -Deleted Oncolytic Adenovirus in Combination with Cisplatin

1 Apr 2006

Abstract excerpt

Oncolytic adenoviruses are currently being developed as novel antitumor therapeutics. To enhance their therapeutic potential, adenoviruses are being administered in combination with standard chemotherapy. Adenoviral vectors used in these clinical trials, however, can be destructive as they encode intact E1B 19-kDa protein, which can block the apoptotic pathway induced by a variety of chemotherapeutic agents....

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PMID: 16610926
DOI: 10.1089/hum.2006.17.379

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